[2] Miller is a co-author of a major introductory college and high school biology textbook published by Prentice Hall since 1990.

In the science community, he has sought to elevate the understanding of scientists of the roots of the creationist movement, and to encourage the popularization of scientific concepts.

In 2002, the Ohio State Board of Education held a public debate between two scientists, including Miller, and two proponents of intelligent design.

In 2005, the judge ruled that the stickers violated the Establishment Clause of the First Amendment to the United States Constitution.

The case was remanded for additional evidentiary inquiry and new findings, and a list of factual issues that the court would probably want to address included as item 15 a reference to Miller's testimony regarding "the colloquial or popular understanding of the term [theory]" and the suggested question as to whether he has any qualifications to testify as an expert on the popular meaning of the word "theory".

He spoke at the Skeptics Society's Origins Conference in October 2008,[11] and at the Veritas Forum on topics such as the relationship between science and religion and the existence of God.

[4] Miller and Levine have also co-written a college-level textbook published by the former D.C. Heath and Company, first edition in 1991, entitled Biology: Discovering Life.

[20] 2006 Dwight H. Terry Lectureship at Yale University, delivering his lecture "Darwin, God, and Dover: What the Collapse of 'Intelligent Design' Means for Science and for Faith in America."