It enters northeastern Christian County about two miles (3.2 km) from the beginning.

It passes through the communities of Fearsville and Fruit Hill and respectively has intersections with Kentucky Routes107 and 800 in that area.

After the junction with KY 181, KY 189 closely follows US 62 from Greenville's northern outskirts and the southern end of Powderly all the way to the route's current northern terminus at another intersection with US 62 just southwest of Central City.

At one time, KY 189 ran concurrently with US 62 from the second junction between the two routes and Central City.

That bypass was also designated as part of the truck route of US 431 and KY 70 on the west side of Central City.