[2][3] US 62 runs concurrently with US 51 for its first 16.17 miles (26.02 km) in Ballard and Carlisle counties in the Jackson Purchase region of southwestern Kentucky.

It then intersects Interstate 24 (I-24) near Whitehaven, the Kentucky Welcome Center, and it runs concurrently with US 45 and US 60, along with parts of the I-24 Business Loop in downtown Paducah.

[2][3] It then intersects I-69 (Western Kentucky Parkway) east of Eddyville before entering Caldwell County.

Near Beaver Dam, after the route's US 231 concurrency through that city, US 62 does cross I-165 (formerly the William H. Natcher Parkway), but without access to that freeway.

[5] In Harrison County, US 62 previously followed a route east of Cynthiana to start its concurrency with US 68 just south of Blue Lick State Park until it was rerouted to its current course to Maysville prior to 1940.

[7] Until 1963, US 62 followed a route from Kuttawa, into what was the inner part of Eddyville, and followed a due easterly path to Princeton via Saratoga Springs.

[9] When I-24's route through Kentucky was completed at some time between 1976 and 1979, US 62's junction with the WK Parkway was closed off as a result of the extension project to extend the WK Parkway to Eddyville to build its western terminus at I-24's exit 42 interchange.