Kentucky Route 2121 (KY 2121) is a 1.780-mile-long (2.865 km) state highway in Owensboro that begins at a junction with KY 2698 following Southtown Boulevard.

It goes next to KY 2127 (Todd Bridge Road).

It makes its way to a junction with KY 2699 (Goetz Drive).

The highway ends at U.S. Route 431 (US 431).

[1][2] The entire route is in Owensboro, Daviess County.