KY 2155 begins at an interchange with Wendell H. Ford Expressway (U.S. Route 60, US 60) and US 231 on the south side of Owensboro.

It continues as a one-way couplet until it reaches East Fifth Street.

[3] The KY 2155 designation came to the road in the 2001–02 fiscal year, when US 231 was rerouted onto the Wendell H. Ford Expressway and US 60 south and east of town to follow a new alignment to the then-new William H. Natcher Bridge into Spencer County, Indiana.

[4][5] From 2002 until 2011, KY 2155 followed the J.R. Miller Boulevard onto the Owensboro Bridge to terminate at the Kentucky-Indiana state line and the Ohio River.

[citation needed] The entire route is in Owensboro, Daviess County.