The expressway begins on the west side of Owensboro at a junction with the original alignment of US 60.

US 231 joins the bypass at the exit for New Hartford Road, and it then intersects Interstate 165 (I-165, the former William H. Natcher Parkway) at that freeway's northern terminus.

The expressway ends at an at-grade intersection with KY 2830, which is part of the original US 60 alignment on the east side of town.

[4] The remainder of the expressway from US 431 to another junction with US 60 on the west side of Owensboro was opened to traffic by 1969–70.

I-67 was planned to go from some point along I-69 in southwest Indiana, and it would follow the eastern part of the expressway and the Natcher Parkway to create a spur from Owensboro to join the I-65 corridor in Bowling Green.