Immediately, it intersects the eastern terminus of KY 116 (Lake Street).

It turns left, to the northwest, and crosses over Harris Fork Creek.

After they split, KY 307 heads to the north-northeast, traveling along the northeastern edge of Fulton, curves to the north, and has an interchange with the Purchase Parkway [future Interstate 69 (I-69)].

The highway continues to the north and leaves the city and then enters Hickman County.

It crosses over Cane Creek and then intersects KY 924 (Kirby Road).

The highway crosses over Pond Branch and intersects KY 1529 (Moscow Water Valley Road).

The highway travels through Kirbyton and intersects the western terminus of KY 548.