It crosses over the North Fork Kentucky River and some railroad tracks of CSX.

It curves to the west-southwest and intersects the western terminus of KY 2448 (Kentucky Boulevard).

The two highways head to the northwest and split on the southeastern edge of Triangle Park.

It crosses over the North Fork Kentucky River on the William D. Gorman Bridge.

It then crosses over some railroad tracks and then Messer Branch before it travels under an overpass the carries KY 15 (Johnny Cox All-American Drive).

After they split, KY 451 winds its way to the west-southwest and makes a gradual curve to the northwest.

KY 451 curves to the south-southwest and begins to parallel some railroad tracks of CSX.

It curves to the west-northwest and crosses over those railroad tracks again and begins to parallel Colwell Fork.

The highway crosses over Eversole Creek before it meets its northern terminus, an intersection with KY 28 in Chavies.

It then meets its northern terminus, an intersection with KY 15 (Johnny Cox All-American Drive).