The highway connects Glencoe and Warsaw, within Gallatin County.

KY 455 begins at an intersection with KY 16 on the east-central edge of Glencoe, within the southeastern part of Gallatin County.

It travels to the west-northwest and enters Glencoe proper.

The highway curves back to the west-southwest and intersects the eastern terminus of KY 465 (Boone Road).

The highway makes a gradual curve to the west-northwest and meets its eastern terminus, an intersection with KY 35 (Sparta Pike) on the southern edge of Warsaw.