The 20.020-mile-long (32.219 km) route traverses eastern Simpson and south-central Warren Counties.

The route begins at a junction with KY 73 about one mile (1.6 km) north of the Tennessee state line.

It enters Warren County before crossing KY 240.

It provides access to I-65 and I-165 via KY 9007 at an interchange in Plano before ending at a junction with Scottsville Road (U.S. Route 231, US 231) on the southern outskirts of Bowling Green.

Kentucky Route 622 is a 20.020-mile-long (32.219 km) state highway that runs from Kentucky Route 73 south of Hickory Flat to TBA via Hickory Flat, Gold City, Temperance,