Ekpenyong attended the University Of Calabar In Cross River State and obtained a Bachelor of Arts Degree in Linguistics and in 1982 obtained a Masters's Degree in International Law and Diplomacy from the University of Lagos.

He functioned In the Programmes Department and worked as an intern under the supervision of Nigerian ace director; Tade Ogidan.

After his NYSC program he was featured in the soap opera Ripples where he played airline pilot Hassan Suleman.

When the Nigerian movie industry began to blossom he switched from soap opera to home videos.

In 2018, the 10th BON edition award show was hosted by Ekpenyong and Nigerian female comedian Helen Paul.