Historically, it is believed that, after the regime change in 1757, Nawab Siraj ud-Daulah's wife and one of his aunts were in prison at Zinzira in Keraniganj.

Strategically, Keraniganj played a vital role during the liberation war of Bangladesh (1971), specially in the guerrilla warfare.

The Pakistani army set fire to many houses in Konakhola, Basta, Brahmankirtha, Ghatarchar, Monohorea, Joynagar, Ramerkanda, Rohitpur, Poraati, Goalkhali and Khagail Kholamora villages.

The freedom Fighters later conducted extensive guerrilla attacks on the Pakistani army and freed Keraniganj Upazila forever.

[citation needed] The Bangladesh government has a plan to integrate Keraniganj Upazila into Dhaka municipality in the near future, to accommodate the expansion of the capital.