Her mother, Lynn Sharples, was a professor of English at the Université de Toulon, and her father, Carlisle Wilson, is a violinist and music educator.

After her time in Dallas, she entered the international circuit as a guest conductor for both opera and symphonic repertoire with extensive engagements throughout North and South America, Europe, Asia, the Middle East and Australia.

[8] Her symphonic and concert work has brought her to Los Angeles, St. Louis, San Francisco, Cincinnati, Seattle, Ravinia Festival, Dallas, Houston, New York, Hannover, Aachen, Düsseldorf, Wiesbaden, Munich, Schleswig-Holstein Musik Festival, Paris, Vienna, Milan, Verona, Florence, Prague, Budapest, Moscow, Kyiv, St. Petersburg, Madrid, Bilbao, Oviedo, Bratislava, Zagreb, Reykjavik, Jerusalem, Hong Kong, Beijing, Toronto, Montreal and Caracas, amongst others.

[9] In the summer of 2022, she embarked on a European and North American tour with the orchestra, including an acclaimed performance at the BBC Proms: "Brahms's Symphony No 4 – conducted by Wilson without score and with serious guts – had raw swagger to burn".

[10] To commence her 2022/23 season, Wilson made her Metropolitan Opera debut, conducting Shostakovich's Lady MacBeth of Mtsensk.

Entitled "The Concert of the Invincibles", Wilson led the orchestra and chorus of the Lviv Opera house in a performance of Verdi's Requiem and Ukrainian composer Victoria Poleva's "Bucha Lacrimosa".

[23] In February 2024, a recording of her conducting the Ukrainian Freedom Orchestra playing Beethoven's 9th Symphony was released by Deutsche Grammophon.

In April, she conducted two fundraising galas in support of Ukraine; one in Berlin with the DSO, and one with the Kyiv Camerata and Joyce DiDonato at Cargengie Hall.

In a feature article about her in the April 2004 American edition of Vogue magazine she says it was during her time at Juilliard that she came to feel her height was an asset rather than a liability, saying.