He is best known for portraying Vasiliy Fet in The Strain, Joshua in Dark Angel, Martin Keamy in Lost, Fred J. Dukes / The Blob in X-Men Origins: Wolverine, Barry Burton in Resident Evil: Retribution, Gabriel in Legion, Little John in Robin Hood, Jeeves Tremor in Smokin' Aces, Carlos in The Butterfly Effect, and Proximus Caesar in Kingdom of the Planet of the Apes.

[4] He often portrays characters on both sides of law enforcement, such as Booth in Walking Tall, sidekick Red in Wild Hogs, psychotic neo-nazi Jeeves Tremor in Smokin' Aces, the title role in Otis E., Gabriel in Legion, Little John in Robin Hood, Officer Caruso in Fruitvale Station, and hired thug Tucker in the 2007 remake of 3:10 to Yuma.

Durand has played series regulars on shows such as Joshua in Dark Angel, Vasiliy Fet in The Strain,[9] Harbard the Wanderer in Vikings,[10] Agent Jay Swopes in the American remake of Touching Evil, as well as guest roles on CSI, CSI: Miami, ER, Without a Trace, Dead Like Me and others.

He also recurred on the television show Stargate SG-1 as Lord Zipacna, on Lost as Martin Keamy,[4] and on the DCEU's 2019 season of Swamp Thing as Dr. Jason Woodrue, the Floronic Man.

Durand is currently slated to make his directorial and screenwriting debut, The Hockey Player, which he is co-writing with Adam MacDonald and has been developing since 2010.