Brian Markinson, Kevin Durand and Zach Grenier co-starred.

The series was produced by USA Cable Entertainment, Granada America and actor Bruce Willis' production company Cheyenne Enterprises, and premiered on March 12, 2004.

Although Touching Evil garnered acclaim from television critics, the USA Network deemed it commercially unsuccessful and opted not to renew the series for a second season.

Returning from a year-long psychological leave of absence after surviving an almost-fatal gunshot wound to the head, San Francisco Detective David Creegan (Jeffrey Donovan) is assigned to the FBI's Organized and Serial Crime Unit – a rapid-response, elite crime investigation squad – where he and his new partner, Detective Susan Branca (Vera Farmiga), find themselves committed to saving lives and solving cases.

In spite of his inability to abide by common sense and the laws he is sworn to uphold, Creegan, with the help of Branca, works on hunting down the most vicious criminals on the streets.