He soon relocated to Los Angeles and landed in the mailroom at International Creative Management (ICM), before moving to the InterTalent Agency as an agent assistant.
Misher ascended the ranks quickly, and during his six years at Tri-Star, oversaw numerous productions, including Donnie Brasco, directed by Mike Newell and starring Al Pacino and Johnny Depp and the sports classic Rudy.
During his tenure, while Universal enjoyed unprecedented success, Misher supervised production on some of the studio's most acclaimed features, such as Out of Sight and Erin Brockovich, as well as initiating four of their most profitable franchises: the series of films spawned by The Mummy, Meet the Parents, The Fast and the Furious, and The Bourne Identity.
In 2019, he produced Stephen Merchant's Fighting with My Family, which stars up-and-coming British actors Florence Pugh and Jack Lowden, along with Nick Frost, Lena Headey, Vince Vaughn and Dwayne Johnson for MGM/Annapurna.
Misher is also readying the sequel to the comedy classic Coming to America with Eddie Murphy for Paramount Pictures; and a movie version of the iconic children's character Carmen Sandiego, starring Gina Rodriguez for Netflix, is to be released.