The Chicago Cubs selected Orie with the 29th pick in the first round of the 1993 Major League Baseball draft.

[1] Orie made his Major League Baseball debut on April 1, 1997, as a member of the Chicago Cubs.

Orie was a finalist in the 1997 MLB Rookie of the Year Award balloting, losing out to the eventual winner, Scott Rolen.

Orie had a role in Kerry Wood's near perfect game on May 6, 1998, where he threw a one-hit, no walk, 20-strikeout shutout against the Houston Astros, tying Roger Clemens' record for strikeouts in a nine-inning game and breaking Bill Gullickson's single-game rookie record of 18 strikeouts in 1980.

[2] Although Orie put together an impressive spring training with the Dodgers prior to the 2000 season, the club already had two established third basemen on their roster: Adrián Beltré & Dave Hansen.

Over the next three years, Orie was signed by three more teams: the Cleveland Indians, Houston Astros, and Milwaukee Brewers.

Many thought that Orie still had the potential to stick in the major leagues and serve as a valuable backup third baseman for a number of teams.