He played in Major League Baseball (MLB) for the New York Mets, Cleveland Indians, Boston Red Sox, and Texas Rangers.

[4] As a freshman at Purdue University in 2010, Plawecki had a .343 batting average, a .384 on-base percentage (OBP), and a .529 SLG, with eight home runs.

[6] Following his freshman season at Purdue, Plawecki played collegiate summer baseball for the Richmond RiverRats of the Prospect League, where he batted 65-for-211 (.308) with fifteen doubles and 27 RBIs.

[9] In the 2012 season as a junior, Plawecki hit .359 batting average, a .445 on-base percentage (OBP), and a .578 SLG, with seven home runs.

[22] After batting .326 for Binghamton, the Mets promoted Plawecki to the Las Vegas 51s of the Triple-A Pacific Coast League on June 24.

[21] The Mets invited Plawecki to spring training in 2015, and reassigned him to minor league camp so that he could start the 2015 season with Las Vegas.

[23] After Travis d'Arnaud went on the disabled list with a broken hand on April 19, 2015, the Mets announced they would promote Plawecki to the major leagues.

[25] During a game against the New York Yankees on April 25, 2015, Plawecki hit his first career home run off CC Sabathia en route to an 8–2 victory.

[26] Plawecki became the first player to hit his first career home run in a Mets-Yankees Subway Series game.

[34] On January 6, 2019, the Mets traded Plawecki to the Cleveland Indians in exchange for Walker Lockett and Sam Haggerty.

[41] Plawecki was placed on the injured list with a left hamstring strain on June 22,[42] and returned to the team on July 9.

[38] He also played in five postseason games, batting 1-for-7, as the Red Sox advanced to the American League Championship Series.

[38] On December 1, 2021, Plawecki and the Red Sox agreed to terms on a one-year contract for 2022, reportedly worth $2.25 million.

Plawecki missed a week of action in late April, spending time on the COVID-related list.

[46][47] On September 17, Plawecki was designated for assignment, as the team added pitcher Frank German to the roster, and was released two days later.

[50] He failed to make the Pirates’ Opening Day roster in spring training and was released by the team on March 27.