On 8 July 2010 he was traded, along with Kirk Hinrich and cash considerations, to the Washington Wizards in exchange for the rights to Vladimir Veremeenko.

On 30 June 2014 the Wizards tendered a $3.89 million qualifying offer to make Séraphin a restricted free agent.

[13] On 17 February 2019 he won 2019 Copa del Rey, recording six points and one rebound in a 94–93 win over Real Madrid.

[14][15] Séraphin was named to the All-Tournament team of the 2009 FIBA Europe Under-20 Championship, after helping France to win the silver medal.

He was a member of the senior French national basketball team in 2011, where France reached the finals of the EuroBasket 2011, which they lost to Spain.