He played in MLB for the Kansas City Royals, Milwaukee Brewers, Oakland Athletics, and Cleveland Indians.

[1] He has also served as the hitting coach for the Royals, Arizona Diamondbacks, Toronto Blue Jays, and Atlanta Braves.

Seitzer hit .323 with 15 home runs and 207 hits (tying the MLB record) in his rookie 1987 season and, though overshadowed by fellow rookie teammate Bo Jackson, he was selected to the American League All-Star team.

Seitzer finished the 1987 season as the runner-up for the American League Rookie of the Year award, behind the Oakland A's Mark McGwire.

In 1993 Seitzer became a free agent, signed with Oakland and after a slow start was released at the All Star break that season.

Seitzer batted .326 with 13 home runs and 78 RBI in '96 while posting a career-high .416 on-base percentage.

[9][10] On November 25, 2024, Seitzer was hired by the Seattle Mariners to serve as the team's hitting coach.

[17] His son Cameron was an infielder in the Chicago White Sox organization from 2011 to 2018; he is now a coach for the Great Falls Voyagers.