Ware received widespread media attention when he suffered an open fracture of the tibia in his right leg during an Elite Eight game against the Duke Blue Devils on March 31, 2013.

In his sophomore year, his minutes began to increase as Louisville's first guard off the bench to relieve Peyton Siva or Russ Smith.

[10] On March 31, 2013, in the first half of an Elite 8 game against Duke, Ware landed awkwardly on his right leg after attempting to block a shot, causing an open fracture which protruded several inches out of his shin.

As the game concluded, Louisville forward Chane Behanan wore Ware's jersey in a show of solidarity for his teammate.

[13] Many NBA players showed their support for Ware and shared their sympathies through Twitter, including LeBron James, DeAndre Jordan, Kobe Bryant and Kevin Durant.

[14] Former NFL quarterback Joe Theismann and the Louisville Cardinals former running back Michael Bush, who both have gone through the same kind of injury, called to give their support.

[15] Ware traveled with the team to the Final Four in Atlanta,[16] where he sat alongside his teammates as they won the national championship game (which was later vacated due to the 2015 sex scandal).

[19] Ware was named the Most Valuable Player of the 2015 Sun Belt Conference men's basketball tournament in which he led Georgia State to victory in the championship game, earning GSU a ticket to the NCAA tournament where they upset third seeded Baylor in the first round, before falling to Xavier in the second round.