He reached a contract buyout agreement with the Grizzlies in March 2021 and joined the San Antonio Spurs in free agency.

Dieng attended the Sports for Education and Economic Development (SEEDS) Academy in Thiès, Senegal.

[5][6] Dieng transferred to Huntington Prep in West Virginia for the 2009–10 school year, where he played for coach Rob Fulford.

Louisville assistant coach Walter McCarty, who has NBA experience, helped Rick Pitino land Dieng in a Cardinals uniform.

[8] Dieng was ruled ineligible by the NCAA when he first arrived at Louisville forcing them to hold him out of practice and individual workouts.

[12] As a sophomore, Dieng started at center for the 2011–12 Louisville team that reached the Final Four of the NCAA tournament.

[13] On March 22, 2012, Dieng matched a Louisville tournament record with 7 blocks in a game in a 57–44 Sweet 16 victory over Michigan State.

[14] Dieng was named as a student representative to the board of directors of the U of L athletic department for the 2012–13 school year, succeeding his graduated teammate Kyle Kuric.

[15] Despite being a junior, Dieng was honored on Senior Day in 2013, due to the fact that he would forgo his last year at Louisville to enter the 2013 NBA draft.

[18] On April 11, also against the Rockets, Dieng scored the game-winning basket with 4.6 seconds left and finished with 12 points and 20 rebounds.

[27] On March 30, 2017, he recorded 11 points, a season-high 15 rebounds, six assists and three blocks in a 119–104 win over the Los Angeles Lakers.

[39] On December 9, 2023, Dieng revealed in an interview with the San Antonio Express-News that he had officially retired from professional basketball.

He set up the Gorgui Dieng Foundation in 2015, which has provided aid including medical equipment and supplies to improve healthcare in his native Senegal.