He played college football for the USC Trojans, and was selected by the Indianapolis Colts in the fourth round of the 2013 NFL draft.

As a senior offensive lineman at Mater Dei High School in Santa Ana, he was named a Prep Star All American.

Trojan teammates Matt Barkley, Victor Blackwell and Max Wittek also prepped at Mater Dei in 2007.

Holmes enrolled in the University of Southern California, where he played for the USC Trojans football team from 2009 to 2012.

[2] On April 27, Holmes was taken in the fourth round, with the 121st overall pick, of the 2013 NFL draft by the Indianapolis Colts.