He is the eldest son of Sheikh Mohamed bin Zayed Al Nahyan, 3rd President of the United Arab Emirates.

[13][14] Sheikh Khaled is a member of Abu Dhabi's Supreme Council for Financial and Economic Affairs.

[23][24][25][26] Sheikh Khaled is one of the Emirati figures who are mentioned in the Pandora Papers due to his partnership with an offshore investment company.

[27] He involves in these activities through the Desroches Island Limited company of which Khalid is the sole shareholder.

[27] His wife is Sheikha Fatima bint Suroor Al Nahyan, and they have two daughters and one son:[28] His brother is Theyab bin Mohamed bin Zayed Al Nahyan, member of the Executive Council, and chairman of the Crown Prince Court, the Early Childhood Authority, Abu Dhabi Transport Company, and Etihad Rail.