He received his early education in Lucknow but was later sent to Lahore and graduated from Punjab University.
He began his film career as a script and dialogue writer with Information Films of India, in 1945 after moving from Lahore to Mumbai.
Khalique was a well-known early documentary filmmaker of Pakistan.
His films were exhibited the world over including at Cannes, Paris, London, Berlin, Moscow, Leningrad, New York City and Beijing during the 1960s and '70s, and he won more than 20 prizes including merit awards from international festivals[citation needed], Tamgha-i-Imtiaz in 1969[citation needed] and a Lifetime Achievement Award from Karafilm Festival in 2003 [citation needed].
He was also a poet and writer of some merit, with a number of publications.