She won the May 1958 supplementary elections for Luang Prabang and became a member of the National Assembly of Laos.
It was during this time that the Boupha couple was actively involved with the Pathet Lao communist movement in Vietnam.
[1] In 1979, Khampheng became a member of the newly formed Lao Front for National Development's Standing Committee and three years later was elected to the Central Committee of the Lao People's Revolutionary Party.
She also served as president of Lao Women's Union and Secretary of State for Rural Affairs.
[3][4] In 1943, Khampheng married Khamphay Boupha,[1] who served as the Laotian deputy minister of foreign affairs from 1975 to 1985.