Khan Shaykhun (Arabic: خَان شَيْخُون, romanized: Khān Shaykhūn) is a town in the Maarrat al-Nu'man District, within the southern Idlib Governorate of northwestern Syria.

[3] Nearby localities include Hbit to the west, Kafr Zita to southwest, Murak to the south and Al-Tamanah to the east.

The city was first settled in the 20th century BC during the Bronze and Iron Ages and had multiple civilisations, of which at least 4 are confirmed through excavations done by the French in 1932.

[2][10] The tell, which measures about 200–250 m long by 18–24 m high, was levelled off in the Bronze and Iron Ages to provide a platform for a series of walled towns built successively on top of each other.

[5]In more recent times, Khan Shaykhun was noted for its beehive houses, an architectural style found across the Levant and probably exported from there to North Africa.

[12] Over the years, Khan Shaykhun has produced many prominent figures, including politicians, intellectuals, and significant individuals in the fields of science, administration, and the military.

[21] Jets believed to belong to the Russian Air Force destroyed the town's power plant, which feeds northern Hama and southern Idlib.

[23] On 27 February 2018, pro-government media reported that Tahrir al-Sham withdrew from the city of Khan Shaykhun, and was expelled from western Aleppo by other rebel groups.

[24] In mid-April 2018, pro-opposition media reported that Tahrir al-Sham once again seized the town, which had been devoid of rebel military presence.

[29] The next day, the Syrian Observatory for Human Rights reported that rebel and Islamic factions and jihadi groups withdrew from Khan Shaykhun completely.

[30] On 21 August 2019, the Syrian Army fully secured the town after capturing the strategic hill of Tell al-Tara and Al-Khazanat Camp in southern Idlib.