[3][1] Hossain was born in Khirai Pachuria Village of Ghior Upazila, Manikganj District, East Bengal, British India on 1 February 1933.

[4] Hossain took a teaching job at Murari Chand College in Sylhet after completion of his studies in the economics department.

[4] In 1964, he served as the chief of the Manikganj subdivision election monitoring committee for Fatima Jinnah, the Combined Opposition Party candidate.

[4] In the 1970 Pakistani general election he stood as a nominee of the National Awami Party faction led by Muzaffar Ahmed.

[5] Hossain worked as an organizer in the Bangladesh Liberation War and was a Revolutionary Command Council member in Manikganj.

[4] In 1978, Hossain joined Military dictator[6] President Ziaur Rahman's political party, the Jatiyatabadi Ganatantrik Dal.

[8] After former Prime Minister and chairperson of the Bangladesh Nationalist Party, Khaleda Zia, was detained on 3 September 2007 she expelled general secretary Abdul Mannan Bhuiyan and replaced him with Hossain.

[10][11] Rapid Action Battalion officials anonymously accused Hossain's son of being involved in the Ya ba trade to The Daily Star.

[12] The Daily Star would later admit it wrote articles against politician during this time using information supplied by Directorate General of Forces Intelligence and was not verified.

[13] On 31 October 2007, Hossain resigned from the post of secretary general of the Bangladesh Nationalist Party from BIRDEM where he was under treatment.

[20] He made major concessions from the caretaker government to participate in the elections despite Khaleda Zia asking him to take a less confrontational stance.

[27] In June 2010, Hossain gave the official response of the opposition Bangladesh Nationalist Party to the national budget describing it as ambitious but difficult to implement.

[30] Police obstructed a human chain of Hossain in front of the Jatiya Press Club which led to the death of one party activist.

[33] His other son, Khandaker Akhter Hamid Khan Paban, was convicting of assaulting police officers during protests in 2018.

Abdus Shahid, Zainul Abdin Farooque, Moudud Ahmed, Jamiruddin Sircar among others attended his funeral.