Lyonpo Khandu Wangchuk (Dzongkha: མཁའ་འགྲོ་དབང་ཕྱུག, born 24 November 1950 in Paro) is a political figure in Bhutan.

He graduated from St. Stephen's College, University of Delhi.

On 7 September 2006, he became Prime Minister again; he was then replaced by Kinzang Dorji on 2 August 2007, after Wangchuk resigned to participate in the 2008 election as a member of the Druk Phuensum Tshogpa (DPT) political party.

[citation needed] Following the DPT's victory in the March 2008 election, Wangchuk became Minister of Economic Affairs on April 11, 2008.

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