In 2022, Willis announced his retirement from professional sports to pursue a career in the Christian ministry.

The Colts traded two fourth round picks (129th overall and 135th overall) in the 2019 Draft to the Oakland Raiders in order to move up and select Willis.

[7] In Week 1 of the 2020 season against the Jacksonville Jaguars, Willis recorded his first career sack on Gardner Minshew during the 27–20 loss.

[8] In the following week's game against the Minnesota Vikings, Willis recorded his first career interception off a pass thrown by former Spartan Kirk Cousins during the 28–11 win.

[9] In Week 14 against the Las Vegas Raiders, Willis intercepted a pass thrown by Derek Carr and returned it for a 50-yard touchdown during the 44–27 win.