Khatsun Namkha Lekpa Gyaltsen (1305 - 1343), orthographic spelling mK'as btsun nam mk'a legs pa'i rgyal mts'an, was a ruler of Sakya, which had a precedence position in Tibet under the Yuan dynasty.
Khatsun Namkha Lekpa Gyaltsen was one of the thirteen sons of the previous abbot-ruler (dansa chenpo) of Sakya, Zangpo Pal.
Yesün Temür tried to strengthen the position of Sakya by appointing his brother Sonam Zangpo as viceroy of the three cholka (regions) of Tibet: Kham, Amdo and Ü-Tsang.
The near-contemporary historian Ziauddin Barani, on the other side, states that the sultan strove to conquer the mountain of Kara-jal between Hind and China.
In order to stop the ambitious Phagmodrupa lord, the Sakya official Wangtson treacherously arrested Changchub Gyaltsen in 1336.
However, the Zhitog and Rinchengang branches of Sakya had a clash in 1341, and Khatsun was forced to step down, leaving the dignity to his brother Jamyang Donyo Gyaltsen.