The Kherson Regional Committee of the Communist Party of Ukraine, commonly referred to as the Kherson CPU obkom, was the position of highest authority in the Kherson Oblast, in the Ukrainian SSR of the Soviet Union.
The position was created in April 1944, and abolished in August 1991.
The First Secretary was a de facto appointed position usually by the Central Committee of the Communist Party of Ukraine or the First Secretary of the Communist Party of Ukraine.