Khertvisi is a village in Aspindza Municipality of Samtskhe-Javakheti region, the Republic of Georgia.

Situated at the confluence of rivers Mtkvari and Paravani, the village was set on a number of terraces.

According to the chronicles, in ancient times Khertvisi was a town.

The large Khertvisi Fortress was built here presumably in the 10th-11th centuries.

In 1771, when the fortress was temporarily taken back from Turks by the King Erekle II, a large amount of valuables and goods was evacuated.