Khlong Om Non (Thai: คลองอ้อมนนท์, pronounced [kʰlɔ̄ːŋ ʔɔ̂ːm nōn]) is a branch of the Chao Phraya River in Nonthaburi Province, part of Greater Bangkok.

The khlong was originally the river's main watercourse, but became reduced when a bypass canal was dug in accordance with the orders of King Prasat Thong in the middle of the late Ayutthaya period to reduce the distance between Ayutthaya and the sea.

[1] Khlong Om Non is currently a waterway that is separated from the Chao Phraya River at Mueang Nonthaburi District, then enters Bang Yai District to the south, then flows into the Chao Phraya River in Bang Kruai District (where it is referred to as Khlong Bang Kruai), with a total length of 17.5 km (10.9 mi).

Later, in 1549–1550 during the reign of King Maha Chakkraphat, many people from Ayutthaya Kingdom to settle here after the war with Hanthawaddy.

The two sides are filled with many tourist attractions such as many ancient temples and antique wooden traditional Thai houses or durian estates with eateries.