He was a member of a powerful family of nomarchs and officials which was likely founded by his grandfather Khnumhotep I and housed in Men'at Khufu.

[1]: 110–1 [2]: 1, 26 Khnumhotep's biography is recorded on the inner doorway of his rock-cut tomb in the eastern cliffs above Beni Hasan, and he visited both Byblos and Punt.

Like her husband, Khety held a remarkable number of titles such as daughter of a governor, king's acquaintance, foremost of actions, lady of the house, and was also a priestess of Hathor and Pakhet.

Those peculiarities and the fact that both consorts appears several times in Khnumhotep's tomb suggests that the one between him and Khety was likely a politically arranged marriage while Tjat could have been his true love who was appointed sealer by him in order to have her closer.

The rock around the doorway leading inside the tomb to the chapel was smoothed and flattened, on which a fourteen line inscription is giving the list of the festal days for the services of funeral offerings, called percheru, along with the name and titles of Khnumhotep II.

[4]: 53  The floor of the main chamber (also referred to as the chapel) is sunk into the ground below the level of the open outer court and is descended into by three steps.

[2]: 32  At the back of this main room (east wall) is a small rectangular shrine approached by a step about 13 centimetres (5.1 in) high.

On the eastern end of the north wall there is a large-scale standing figure of Khnumhotep II receiving offerings primarily of several types of animals and birds.

The west end of the wall has another large-scale figure of Khnumhotep II only here he is facing right and using a bow to hunt in the desert which is on the edge of the Egyptian world, the boundary between order (maat) and chaos.

[2]: 125  The shrine portrays a smaller version of the offering cult and in many ways can be seen as an expansion from the false door of the Old Kingdom, where a statue inside a niche could have been integrated.

[7] What makes this tomb stand out among the 39 large rock-cut tombs at Beni Hasan is the well known scene of the Aamu group from Shu, Asiatic nomadic traders who are sometimes considered Hyksos or at least their forerunners; the group, led by a man called Absha (or Abisha, Abishai), was bringing offerings to the deceased.