The station opened on April 1, 1933, as part of the Northeastern Line Nakhon Ratchasima–Khon Kaen section.

On June 24, 1941, the line extended to Udon Thani.

The station was rebuilt as the first elevated station of Northeastern region in 2019, with the Thanon Chira Junction–Khon Kaen double-track railway project.

As of November 2021, 6 trains serve Khon Kaen railway station.

This Thai railway station-related article is a stub.