[3] Between 1979 and 1981, Northeastern organized a blue-ribbon panel of educators and experts, including industry leaders from Bell Labs, University of California, Berkeley, Massachusetts Institute of Technology (MIT) and the Digital Equipment Corporation, to develop a plan to advance education and research in the emerging field of computer science.

The college was initially housed in Knowles-Volpe Hall, now known as the Asa S. Knowles Center, with 11 faculty members and 239 first-year students.

A year later, the college moved into the former Botolph Building, one of the oldest structures on campus, which reopened as the David and Margaret Fitzgerald Cullinane Hall.

At the end of 1987, the CCS proposed the Law of Demeter, which was widely used in software development area.

On December 16, 2018, Northeastern University announced a $50 million gift from alumnus and board trustee, Amin Khoury, in order to "support all aspects of the college's future focus."

[6] A two-semester senior capstone project, designed to integrate the many skill sets developed in the program, is required.

in Cybersecurity typically finish the program in two years, with 32 semester hours required to earn the degree.

[11] The PhD program prepares students for research careers in government, industry, or academia.

The joint degree program combines a strong curriculum in human-computer interface technology and experimental design in health sciences.

The following student groups and organizations are part of the Khoury College community: Students of the college also participate in a variety of information security competitions, most notably the National Collegiate Cyber Defense Competition.

The co-op program allows students to take semester-long internships with public and private-sector organizations, exposing them to the real world application of the skills and knowledge taught in their academic major.

Nearly two-thirds of Khoury College's graduating students are offered full-time positions by the companies for at which they worked a co-op.

[21] Companies that participate in this program range from small startups to large enterprises including Google, Microsoft, John Hancock, and Amazon.com.