Nurse played basketball while attending St. Thomas More Catholic Secondary School in Hamilton, Ontario.

During her playing career, she helped the team win three consecutive OFSAA high school championships in 2011, 2012 and 2013.

[2] In her time at UConn, Nurse played under head coach Geno Auriemma, alongside players such as Breanna Stewart, Gabby Williams and Napheesa Collier.

After signing her letter of intent, she revealed that she had recorded a goal of playing for Connecticut when she was in Grade 7.

[4] Nurse would join the Liberty alongside players such as Tina Charles and Epiphanny Prince.

Nurse made her WNBA debut on May 20, 2018, scoring 17 points in an eventual 80–76 loss to the Chicago Sky.

[5] In June 2018, Nurse scored 34 points, a season-high amongst WNBA rookies, in the Liberty's 87–81 overtime victory over the Indiana Fever.

[6] In July 2019, Nurse was named as a starter for the WNBA All-Star Game for the first time in her career.

[13] Nurse was invited to play on the under-17 national team in the FIBA Under-17 World Championship for Women, held in Amsterdam in 2012.

[14][15] Nurse was invited to join the national team, to play in the 2013 FIBA Americas Championship for Women, held in Xalapa, Mexico from September 21–28, 2013.

She averaged ten points per game and helped the Canadian National team to a second place, silver medal finish.

Canada led by only six points at halftime but gradually expanded the lead to end up with an 83–66 win and a spot in the gold-medal game.

Nurse was the leading scorer for Canada with 20 points, and her overall performance earned her the MVP award for the entire event.