Though the location of this is now unknown, the Kiawah were granted a land request for a reservation south of the Combahee River.

A Kiawah native called the Casseeka (cacique or leader) assisted in the travels of Cartaret, who remarked that he was "a very ingenious Indian, and a great linguist.

[6] The British colonial government granted land to the south of the Combahee River to a Kiawah chief.

[7] The Kiawa were last recorded as living near Beaufort, South Carolina, in the 18th century, and Swanton writes they likely "gradually merged in the surrounding population.

Severe population depletion is said to be attributed to smallpox and other diseases in combination with attacks by the Spaniards and Indian allies of the French.