[3] Early films in Shipka's career include Carriers (2009), Flowers in the Attic (2014), and The Blackcoat's Daughter (2015), and Totally Killer (2023), as well the television miniseries Feud: Bette and Joan (2017).

[5] Shipka made her television debut at five months of age on the hospital drama ER.

In 2010, Austin American-Statesman critic Dale Roe named her as his dream nominee for the Primetime Emmy Award for Outstanding Guest Actress in a Drama Series, writing, "This 10-year-old actress was so affecting as troubled Sally Draper last season that it seems odd that she's only just been upgraded to series regular.

If Shipka's upcoming Mad Men work—struggling with the broken marriage of her parents and entering preteendom in the tumultuous 1960s—remains as amazing as it was in season three, this is a ballot wish that could come true next year.

[14] Shipka starred in the 2014 Lifetime movie Flowers in the Attic, and co-starred (with Emma Roberts) in the 2015 Oz Perkins horror film The Blackcoat's Daughter.

[17] Shipka reprised the role in a sixth-season episode of Riverdale, “Chapter Ninety-Nine: The Witching Hour(s)", aired on December 7, 2021.

"[23] In May 2021, Shipka was cast in the HBO political drama limited series White House Plumbers.

[28] In October 2023, Shipka starred alongside actress Olivia Holt in Amazon Prime Video's 1980s horror-comedy Totally Killer.