Chuck Connors headlines an ensemble cast that also includes Frank Wolff, Franco Citti, Leo Anchóriz, Giovanni Cianfriglia, Alberto Dell'Acqua and Hercules Cortez.

[4] The story centers around a gang of robbers, whose boss (Connors) is tasked by a Confederate captain (Wolff) with stealing gold from a Union fort, before wiping out all of his men to save on their share of the booty.

The gang is summoned to a Confederate town and hired to steal the $1 million in gold secretly stored by Union troops inside Todos Santos, an old mission they ostensibly use as a gunpowder repository.

MacKay's crew Military personnel Sergio Citti, Vincenzo Maggio, Osiride Pevarello and Pietro Torrisi also appear in stunt roles as soldiers.

[10]: 213  The Todos Santos mission was integrated atop the mountains surrounding Las Salinas thanks to matte painting from veteran Spanish effects artist Emilio Ruiz.

[22] Kill Them All and Come Back Alive has received mostly positive reviews, and has gained plaudits over time, as the film's action focus grew more aligned with modern filmgoers' sensibilities.

In the U.S., trade magazine Boxoffice noted the film's "handsome" look and commanded Castellari for pacing the action "briskly enough", as well as Connors for bringing to his role "a casualness befitting of a n'er-do-well more than willing to cast his fate on the wind".

[30] Louise Boyka of the Schenectady Gazette praised the film's action, writing that heist was pulled off in "amazing fashion, with some of the most spectacular stunt scenes that I have seen in ages".

She noted that Connors' "pretty heartless" character differed from his usual good guy roles, "but then this is spaghetti western, filmed in Rome, and morality is never a strong point in these epics.

"[31] In Italy, communist paper L'Unità disapproved of the film's amorality, pointing to its "sad and depressing vicissitudes", and adding that its colors and widescreen only exacerbated the characters' small-mindedness.

Calling it "a western with irony", it found that the title did not fully reflect its content, which continued the director's habit of "facetiously exploring certain situations that are usually solely presented through the prism of ferocity".

"[18] Film historian Roberto Curti wrote: "Of Castellari’s first films—all of them Westerns—Ammazzali tutti e torna solo, starring Chuck Connors, definitely stands out with its unusual seaside setting and pop culture influences.

"[35] Leonard Maltin was most positive, hailing the film as a "[h]ighly entertaining, action-packed spaghetti Western with nonstop fistfights, gun battles, and explosions, plus some clever plot twists.

[45] Select tracks have appeared on several CD compilations dedicated to De Masi's works or Western films in general,[44][46] before the full tracklist was re-issued by Beat Records as part of their limited edition Gold Series in 2011.