It represents the official film debut for director Enzo G. Castellari of Few Dollars for Django.

Following the American Civil War a bunch of deserter Confederate soldiers dwell in Mexico and make a living on terrorising the villages around.

Bounty hunter Stuart and his assistant Manuela put a crackdown on these misdeeds.

Payment in Blood was described by Italian film historian Roberto Curti as Castellari's "official" debut, as it was the first time the director was credited as a director after going uncredited on films such as Some Dollars for Django and A Ghentar si muore facile.

of Variety described Payment in Blood as "a gamy slapdash and overly violent Civil War oater drama, made by crude Italian film hands and probably exported in hopes that names of Edd Byrnes and Guy Madison might have the b.o prospects.