Andrews is intent on formulating a deadly drug that would make any creature injected with it succumb in a matter of seconds.

The jungle explorer advises him to leave quickly, as rumour has it that a creature (Max Palmer), half-man and half-ape, roams the canyon's grounds.

Meanwhile, Ramada has learnt of Andrews' scheme and decides not to let him harm the jungle animals anymore.

Jim's pet chimpanzee Tamba ropes in his fellow ape friends and together they storm into Andrews' retreat.

The Killer Ape angrily massacres all of Andrews' henchmen and lets the doctor be mauled to death by a panther.

[1] The then-owner of the movie ranch Corriganville, American actor Ray "Crash" Corrigan, made a cameo appearance in the film.

[2] Archived footage from Captive Girl (1950) was incorporated in the film for a scene involving primates ambushing a scientist's retreat.

[4] Variety wrote that the film was "[a] stereotyped entry in Johnny Weissmuller's 'Jungle Jim' series of programmers".

The Columbia Story commented that "more talk than action characterized this adventure", while the Motion Picture Guide found it to be "a cliché tour-de-force replete with bad acting and apathetic direction".