[1][2] Writer/director Mark Weidman quit his day job as a teacher and, along with his brother-in-law Chip Smith, formed Smile House Production in order to make the film.

[1] The film centers on four aspiring filmmakers, Rome, Buzz, Max, and One-Eye, who go on a surreal rampage and make their exploits into a movie.

[3] DVD Talk gave a mostly negative review that opined that the commentary track might be useful for prospective indie low-budget filmmakers, but that the movie itself was "weak" and "tough to sit through".

[4] Kevin Thomas of the Los Angeles Times gave a brief but enthusiastic review that called Killer Flick "an outrageous, inspired satire".

The reviewer felt that director Weidman cut to rehearsals where the actors to be killed off try out various bits of dialog, and in noting the cast agreeing that the film is becoming too "self-referential" s and says so out loud, was astute in "beating the audience to the punch."

"[6] San Francisco Weekly noted "Mark Weidman shows how to graft a grade-Z road movie onto a Brechtian scenario of self-reflexivity and narrative breakdown," and concluded he was able to "make a breathless, funny, inventive film.