The nearest town is Ballinrobe, and the closest city is Galway, roughly 40 kilometers (24 miles) away.
The village lies on the N84 road that links Galway to Castlebar (Irish: Caisleán an Bharraigh) .
A bus service that runs four days a week between Galway and Ballina passes through Kilmaine and also travels through Castlebar.
The local Gaelic Athletic Association club, Kilmaine GAA, was founded on 9 March 1937.
The first competitive game ever played by a Kilmaine team was against Castlegar (Claremorris), in Curran's field.