Kilosa District covers 14,918 square kilometres (5,760 sq mi).

Kilosa District is home to Mikumi National Park.

According to the 2022 Tanzania National Census, the population of the Kilosa District was 617,032.

[2] The nine 1997 divisions were: As of 2002[update], Kilosa District was administratively divided into forty- six wards:[4] In 2012 the following eight wards became part of the newly created Gairo District: The thirty-eight wards remaining in Kilosa district from 2012: The town of Kilosa has a station on the Central Line of Tanzanian Railways.

It is also a junction for a branch railway to the break-of-gauge transshipment station at Kidatu.