He also discovered the oncogenic variant of AIMP2, designated AIMP2-DX2, as one of the critical factors that determines the survival of lung cancer patients (Plos Genet 7:e1001351, 2011[8]).
], he found that leucyl-tRNA synthetase (LRS) serves as an amino acid sensor for mTOR signal pathway (Cell 149:410, 2012[9]).
In summary, his research is unveiling novel regulatory network mediated by human aminoacyl-tRNA synthetases that have been regarded as housekeeping machinery for protein synthesis.
The regulatory roles and implications of these proteins in human diseases have been largely overlooked for decades.
His series of the discoveries on the new function, pathology and medicine of ARSs are rapidly opening a research area that throws new insights into the central dogma of life and human diseases.