In 2009, at the age of 15, she became the youngest African American woman to complete a transcontinental flight across the United States, from Los Angeles, California to Newport News, Virginia.

[6][7] She was inspired to take lessons after reading about Jonathan Strickland, an earlier participant of the program who became the youngest person to fly a fixed-wing aircraft and a helicopter solo in a single day.

[9] Departing on June 29, 2009,[10] 15-year-old Anyadike flew a single-engine Cessna 172 from Compton, California to Newport News, Virginia and back, completing the journey in 13 days.

[11] In Washington, D.C., Congresswoman Laura Richardson came to congratulate the young pilot, and in Tuskegee, Alabama, Mayor Omar Neal proclaimed July 2 to be "Kimberly Anyadike Day".

[11][1][6][2][9] Upon her arrival home on July 11, 2009, Anyadike received an award from the County of Los Angeles, and was personally invited by Governor Arnold Schwarzenegger to visit the California State Capitol.

[2] In 2017, Anyadike was interviewed about her transcontinental flight for a special Disney Channel segment for Black History Month entitled 'True Heroes Are Timeless'.

[12][13] For her college education, Anyadike enrolled at the University of California, Los Angeles (UCLA), majoring in physiological science with minors in African-American studies and Spanish.