She was educated at Mount Holyoke College where she received a BA in Psychology, and at the University of Chicago where she was awarded her Master's degree in Social Work.
[3][4] In 2012, Hébert Gregory was nominated for Drama Desk Award for Outstanding Featured Actress in a Play for performance in By The Way, Meet Vera Stark.
[5] Hébert Gregory appeared in films I Think I Love My Wife (2007), Red Hook Summer (2012), White Alligator (2012), and The Genesis of Lincoln (2014).
She guest-starred on Gossip Girl, Law & Order, Grey's Anatomy, Private Practice, Two and a Half Men, and The Big Bang Theory.
In 2020, Hébert Gregory was cast as Ruth Jean Baskerville Bowen in the National Geographic anthology series Genius: Aretha starring Cynthia Erivo.