[4] In 1899, the hospital itself was founded by the What-so-ever Circle of the International Order of the King's Daughters and Sons and moved to a seven-room building at 18th Street and Greenup Avenue.

One year after the hospital was expanded upon, the Ashland Medical Arts Building was completed in 1969 at the corner of Lexington Avenue and 23rd Street.

[5] A medical library and health education center was completed in the lower level of the parking garage in 1992.

[3][5] It features a 24-bed Intensive Care Unit, 3 Cardiac Cath Labs bringing the total to five, a Cardiac Cath Lab pre-op and recovery areas, three dedicated Cardiothoracic surgery operating suites, a nine-bed Cardiovascular Recovery Unit, and a rooftop helipad.

In 2000, a new five-story structure was completed along 23rd Street that provided new patient rooms, surgery facilities and Intensive Care Unit.

On May 8, 2006, a new $60 million [10] 200,000 sq ft (19,000 m2).,[6] five-story Heart and Vascular Center, now known as Parkview Patient Tower 2, opened along 23rd Street.

[2] Envisioned as a three-story $43.5 million facility,[11] a rising demand in services relating to cardiac and heart care necessitated the expansion of the hospital while it was under construction.

Center for Advanced Imaging opened along Central Avenue adjacent to the Hospitality House at a cost of $13.3 million.

[12] Construction began in October 2005 and was designed to free up space in the existing hospital complex for inpatient and emergency radiology.

The center is home to outpatient radiology, MRI, CT scans, mammograms, ultrasounds and X-rays; part of the second floor is dedicated to breast care.

The hospital ranks fourth in the state of Kentucky in admissions and with number of employees at 5,000,[3] making it the largest employer between Lexington and Charleston, West Virginia.

The building, which originally housed Ashland Oil's petroleum division, had been donated to the county by Bon Secours Mercy Health as part of the 2020 closing of Russell's Our Lady of Bellefonte Hospital (OLBH).

This allowed expansion of clinical services on the hospital campus and resulted in the creation of approximately 150 additional jobs.

[19][20][21][22] On January 29, 2021, the hospital and the University of Kentucky announced a "significant partnership" between King's Daughters and UK HealthCare.

King's Daughters then-President and CEO Kristi Whitlatch remained in that role but will also become a member of UK HealthCare's management team.

[23] The partnership, which includes access to UK HealthCare's pediatric cardiology and pharmacy program as well as expanded access to the Markey Cancer Center and training opportunities within King's Daughters for University of Kentucky College of Medicine students, officially went into force on April 1, 2021.